Pentazocine, A Powerful Pain Reliever

Pentazocine is a drug with analgesic  properties . Pain relievers generally relieve pain.

There are many different types of pain relievers, and each has its benefits and risks. Also, some pains respond better to certain medications. In turn, each person may have a slightly different response to different pain relievers.

Pentazocine is used to combat moderate and severe pain.  It belongs to the group of opioids, which are the most powerful pain relievers. They are very effective but can sometimes cause serious side effects. There is also the risk of causing addiction. Therefore, you should only take it under medical supervision.

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Mechanism of action of pentazocine

Pentazocine against pain

Pentazocine works by changing the way the brain and nervous system respond to pain.

In addition to the analgesic effects characteristic of this group of drugs, it also has other effects. It also has antitussive action, sedative effect, respiratory depression and miosis (permanent abnormal contraction of the pupil of the eye). Thanks to its analgesic effects, it is used in moderate to intense pain treatments .

Read also: What is pain?

How Pentazocine is Taken and Disposed of

Pentazocine is a drug for oral, intramuscular and intravenous administration. Although it also accepts the rectal route. The most used administration is oral. It has a good oral absorption and presents the maximum levels in the blood after 15-30 minutes. Its  effect lasts approximately 3 hours.  It is mainly eliminated in the urine.

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Adverse reactions

Adverse reactions Pentazocine

This drug is safe if prescribed by a doctor and the instructions for use are followed. But, if the doses are raised, undesirable psychological effects can appear, such as hallucinations.

It can also trigger the following effects:

  • Respiratory problems.
  • Sweating and hot flashes
  • Blood problems, such as a reduction in certain white blood cells.
  • Nausea and vomiting, constipation, diarrhea, or anorexia.
  • Cardiovascular effects such as hypertension, hypotension, tachycardia.
  • Seizures, dizziness, headache, disturbed dreams.


Pentazocine interacts with many drugs, so caution must be exercised with its administration. Interactions can affect the processes of drug release, absorption, distribution, metabolism, and excretion. They can also enhance or decrease its effects.

Remember that this type of medication must be taken with a prescription and medical supervision. 

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